×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade.
26678033
2016
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
23020132
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
BRAF and RAS mutations in human lung cancer and melanoma.
12460918
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.
20551065
2010
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
24576830
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer.
23524406
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy.
24586605
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
We have treated 45 patients with V600 mutated melanoma including patients with V600R mutation between July 2011 and October 2012 with the selective BRAF inhibitor dabrafenib (n=43) or vemurafenib (n=2) via a compassionate access programme.
23237741
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Missense mutations of the BRAF gene in human lung adenocarcinoma.
12460919
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
In summary, we have identified a group of melanomas with low-activity BRAF mutations that are reliant upon CRAF-mediated survival activity.
18794803
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor.
23248257
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
[Long-term results following surgery or radioiodine treatment of solitary autonomous adenoma of the thyroid gland].
2493360
1989
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Prognostic value of BRAF mutations in localized cutaneous melanoma.
24388723
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers.
12068308
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma.
24583796
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
23614898
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.
22805292
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
20141835
2010
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
19238210
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms.
22351686
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.
22389471
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Genetic predictors of MEK dependence in non-small cell lung cancer.
19010912
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
22972589
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
CausalMutation
CLINVAR
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
23833300
2013